By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the large physique of simple technology and scientific facts linked to adenomatous polyps of the colon, a lot of it encouraged via the belief that the majority colorectal carcinomas appear to come up in such polyps. This publication strives to judge those info, with specific emphasis on their implications for administration of polyp-bearing matters. issues comprehensively explored contain anatomy and histology of the conventional colon; pathologic features of adenomatous polyps, differential analysis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic proof for the malignant power of adenomatous polyps; and detection and administration, with exact realization to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Adenomatous Polyps of the Colon: Pathobiological and scientific beneficial properties consolidates the massive physique of uncomplicated technological know-how and medical information linked to adenomatous polyps of the colon, a lot of it encouraged through the conclusion that almost all colorectal carcinomas appear to come up in such polyps. This publication strives to guage those facts, with specific emphasis on their implications for administration of polyp-bearing matters.
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Additional info for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
Pathology grade amplitude between them and the local pathologists submitting cases to that study (see M. , 1988). Brown et aI. (1985) found substantial inter- and intraobserver disagreement in the histological grading of dysplasia. Their morphometric analysis showed that (1) nuclearlcytoplasmic ratio and (2) variability (standard deviation) of nuclear area and height (but not absolute nuclear area and height) were of value in discriminating between the three grades of dysplasia, but it is unlikely that morphometry will be commonly used in diagnostic pathology.
Wiebecke et al. (1974) suggested that villous adenomas resulted from vertical "foliaceous" growth with groovelike lengthening of crypts. In their stereological study, Elias et aI. (1981) stated that "villi" represented sections of what were really branching folia and that these folia resulted not from proliferating lamina propria, as suggested by Wiebecke et aI. (1974), but from progressive fusion of adjacent crypt epithelial layers and of adjacent lumina in the upper crypts. Irrespective of where in the crypt the initial adenomatous change starts, the main proliferation of adenomatous tissue is indeed toward the luminal surface, resulting in the typical convex upper surface of the classical AP.
Lane N, Lev R (1963) Observations on the origin of adenomatous epithelium of the colon. Serial section studies of minute polyps in familial polyposis. Cancer 16:751-764. Lev R, Grover R (1981) Precursors of human colon carcinoma: A serial section study of colectomy specimens. Cancer 47:2007-2015. Lev R, Lebenthal E, Rossi T, Lance P (1987) Histochemical and morphological analysis of colonic epithelium from children with Gardner's syndrome and adults bearing adenomatous polyps. J Pediatr Gastroenterol Nutr 6:414-425.