By Robert Lev

Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the gigantic physique of uncomplicated technology and medical information linked to adenomatous polyps of the colon, a lot of it encouraged by way of the conclusion that the majority colorectal carcinomas appear to come up in such polyps. This ebook strives to judge those facts, with specific emphasis on their implications for administration of polyp-bearing matters. themes comprehensively explored comprise anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant power of adenomatous polyps; and detection and administration, with distinctive awareness to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.

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Sample text

The latter group demonstrated chromosomal abnormalities consistently in APs: Hyperploidy and structurally abnormal individual chromosomes were more common in the more severely dysplastic or villous tumors. More recently, flow cytometry has been the preferred method of study. Homogenates of nuclei obtained from neoplastic and normal colon are stained and the histograms subsequently generated yield information on DNA ploidy at various stages of the cell cycle. Traditionally, fresh specimens have been the source of the nuclei, but recently paraffin-embedded material has been used.

Histogenesis of Polyps Possible etiological factors in polyp formation such as genetic effects and luminal influences will be discussed in Chaps. D, respectively. There is disagreement as to where in the crypts the initial changes originate. In their study of tiny APs in FPC, Lane and Lev (1963) demonstrated the gradual development of dysplasia in the deep crypt cells as they migrated upward and suggested that the adenomatous epithelium then spread laterally, imparting a ''vase of flowers" appearance to the polyp.

Aust NZ J Surg 56: 717-722. Jarvinen H, Franssila KO (1984) Familial juvenile polyposis coli; increased risk of colorectal cancer. Gut 25:792-800. Jarvis LR, Graff PS, Whitehead R (1987) Correlation of nuclear ploidy with histology in adenomatous polyps of colon. J Clin Pathol 40:26-33. Jothy S, Boucher L, Fuks A (1988) Differential expression of CEA epitopes in colonic polyps correlates with histopathological features. Lab Invest 58:44A. 40 2. Pathology Kalus M (1972) Carcinoma and adenomatous polyps of the colon and rectum in biopsy and organ tissue culture.

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