Forim@ge Books > Nonfiction 9 > 5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

This booklet offers a complete, updated overview of the distribution, pharmacology and body structure of important 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes express a different pharmacology, distribution and serve as, of which the 5-HT4 receptor has been essentially the most intensively studied in recent times, either from a easy study point of view and as a aim for novel therapeutics.

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Med Res Rev 1993; 13:633-662. Eglen RM, Hegde SS. 5-Hydroxytryptamine (5-HT4 ) receptors: physiology, pharmacology and therapeutic potential. Exp Opin Invest Drugs 1996; 5:373-388. Dumuis A, Sebben M, Boeckaert. The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT 4 ) positively coupled to adenylate cyclase in neurons. Naunyn-Schmiedeberg's Arch Pharmacol 1989; 340:403-410. Medicinal Chemistry ofs-HT4 Receptor Ligands 43 7· Bockaert J, Sebben M, Dumuis A.

Cambridge. 1995. 66. Wardle KA, Ellis ES, Baxter GS et al. The effects of SB 204070, a highly potent and selective 5-HT4 receptor antagonist, on guineapig distal colon. Br J Pharmacal 1994; 112:789-794. Medicinal Chemistry ofs-HT4 Receptor Ligands 47 67. Hegde SS, Bonhaus DW, Johnson LG et al. RS-39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br J Pharmacal 1995; 115:1087-1095· 68. Yang DC, Goldstin B, Moorman AE et al. SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophagial tunica muscularis mucosae.

Br J Pharmacol1993; 110:10P. 16. Droppleman DA, Gregory RL, Alphin RS. A simplified method for assesssing drug effects on gastric emptying in rats. J Pharmacol Meth 1980; 4:227-230. 17. Banner SE, Smith Ml, Sanger GJ. 5-HT receptors and 5-hydroxytryptophan-evoked defacation in mice. Br J Pharmacol1993; 110:135P. 18. Bingham S, King BF, Rushant B et al. Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function. J Pharm Pharmacol1995; 47:219-222.

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