By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

This publication offers a complete, updated evaluation of the distribution, pharmacology and body structure of important 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes convey a different pharmacology, distribution and serve as, of which the 5-HT4 receptor has been probably the most intensively studied lately, either from a uncomplicated study viewpoint and as a aim for novel therapeutics.

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Cisapride and a structural analog, R 76186 are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea pig colon ascendens. NaunynSchmiedeberg's Arch Pharmacal 1993; 347:464-470. 54· Kawakita T, Kuroita T, Murozone T. New benzoic acid derivatives are 5-HT4 receptor agonists. Int Pat Appl1997; WO 97/006452. 55· Yoshida, N. Pharmacological studies on mosapride citrate (AS-4370), a gastroprokinetic agent. (1). Comparison with cisapride and metoclopramide. Yakuri to Chiryo 1993; 21:3013-3028. Chern Abst 120:95340 (1997).

16. 5-HT4 receptor antagonist activity of carbazimidamides" compd. H I A ~ N ~oyq I ~ H HOm I A N A N ~ '- HOm I A ~ N '- "Reference 85. bJndol-3-yl group.

Kennet GA, Bright F, Trail B et al. Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats. Neuropharmacol 1997; 36:707-712. 82. Kaumann AJ, King FD, Young RC et al. Indazole as an indole bioisostere: 5-HT4 receptor antagonism. Bioorg Med Chern Lett 1992; 2:419-420. s-HT4 Receptors in the Brain and Periphery 83. Cohen ML, Bloomquist W, Schaus JM et al. LY353433, a potent, orally effective, long-acting 5-HT4 receptor antagonist: Comparison to cisapride and RS-23597-190.

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