By I. Scharrer (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)

This publication comprises the contribution to the thirty seventh Hemophilia Symposium, Hamburg 2006. the most subject matters are epidemiolgy, therapy of inhibitors in hemophiliacs, hemophilic arthropathy and synovitis, appropriate hemophilia therapy 2006, and pediatric hemostasiology. the quantity is rounded off by way of various unfastened papers and posters on hemophilia, casuistics, and diagnostics.

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Ehrenforth S, Kreuz W, Scharrer I, Linde R, Funk M, Gungor, T, Krackhardt B, Kornhuber B. (1992) Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs. Lancet, 339:594–598 2. Hoyer LW (1995) The incidence of factor VIII inhibitors in patients with severe hemophilia A Adv Exp Med Biol, 386:35–45 3. Slifka MK, Antia R, Whitmire JK, Ahmed R (1998) Humoral immunity due to long-lived plasma cells. Immunity, 8:363–372 4. Bernasconi NL, Traggiai E, Lanzavecchia A. (2002) Maintenance of serological memory by polyclonal activation of human memory B cells.

7] for the detection of human memory B cells specific for viral antigens. To establish our method we used tetanus toxin as a control antigen and followed the kinetic of tetanus-specific memory B cells in the peripheral blood of healthy volunteers after vaccination. Fig. 1. Re-exposure of FVIII-specific memory B cells to FVIII and interaction with activated T cells at the same time cause re-stimulation and differentiation of FVIII-specific memory B cells into anti-FVIII antibody-producing plasma cells.

Lang et al. specific for the negative control HSA or for human FVIII at any time (Figs. 4–5). All volunteers developed detectable levels of tetanus-specific antibody-producing cells in their circulation at 7 days after vaccination that disappeared again at later time points. Tetanus-specific memory B cells increased in frequency at about 7 days after vaccination and showed a peak between 11 and 21 days after vaccination. Afterwards they were detectable for the whole observation period of 35 days after vaccination (Fig.

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